Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain
| Autor: | Han Kunyuan, Qinxue Dai, Dan Li, Dongdong Liang, Junlu Wang, Luping Huang, Ming-xiao Zhang, Shuangdong Chen, Sijia Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Electroacupuncture medicine.medical_treatment neuralgia Pharmacology lcsh:RC321-571 Rats Sprague-Dawley receptor A1 de adenosina 03 medical and health sciences Adenosine A1 receptor 0302 clinical medicine Animals Medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Injections Spinal Receptor Adenosine A1 business.industry astrocytes Chronic pain cytokines neuralgia medicine.disease Sciatic Nerve Rats receptor adenosine A1 Disease Models Animal astrócitos 030104 developmental biology medicine.anatomical_structure Nociception Spinal Cord Neurology Eletroacupuntura Astrocytes Xanthines Peripheral nervous system Neuropathic pain citocinas Neuralgia Neurology (clinical) business 030217 neurology & neurosurgery Astrocyte |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 76, Iss 11, Pp 736-742 Arquivos de Neuro-Psiquiatria v.76 n.11 2018 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO |
| ISSN: | 1678-4227 0004-282X |
| Popis: | Objective Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system. Electroacupuncture (EA) has an antinociceptive effect on neuropathic pain, which is partially due to inhibiting astrocyte activation in the spinal cord. Methods We found that an intrathecal injection of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist, reversed the antinociceptive effects of EA in a chronic constriction injury-induced neuropathic pain model. Results The expression of GFAP in L4-L6 spinal cord was significantly upgraded, while DPCPX suppressed the effect of the EA-mediating inhibition of astrocyte activation, as well as wiping out the EA-induced suppression of cytokine content (TNF-α). Conclusions These results indicated that the adenosine A1 receptor is involved in EA actions during neuropathic pain through suppressing astrocyte activation as well as TNF-α upregulation of EA, giving enlightenment to the mechanisms of acupuncture analgesia and development of therapeutic targets for neuropathic pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|