Cerebral microembolism, a disease marker for ischemic cerebrovascular events in the antiphospholipid syndrome of systemic lupus erythematosus?
| Autor: | Ch. Specker, Matthias Sitzer, D. Söhngen, I. Janda, J. Rademacher |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Systemic disease Adolescent Heart disease Ultrasonography Doppler Transcranial Heart Valve Diseases Ischemia Risk Assessment Brain Ischemia Antiphospholipid syndrome Internal medicine medicine Humans Lupus Erythematosus Systemic Risk factor skin and connective tissue diseases Aged Retrospective Studies Chi-Square Distribution Lupus erythematosus Vascular disease business.industry General Medicine Intracranial Embolism and Thrombosis Middle Aged Antiphospholipid Syndrome medicine.disease Connective tissue disease Echocardiography Doppler Cross-Sectional Studies Neurology Cardiology Female Neurology (clinical) business |
| Zdroj: | Acta Neurologica Scandinavica. 99:356-361 |
| ISSN: | 1600-0404 0001-6314 |
| Popis: | Objectives – We investigated whether the detectability of microembolic Doppler signals (MES) in the intracranial circulation may help to define the individual cerebrovascular risk in systemic lupus erythematosus (SLE) with antiphospholipid syndrome (APS). Material and methods – Retrospective cross-sectional study of 70 patients with SLE with or without APS, and 30 controls with a history of cerebral ischemia of unknown cause. Of all patients, 38 had a clinical history of APS and 32 did not. Results – 15 patients with APS (39%) showed MES. In contrast, all patients without APS and 29 of 30 controls were microemboli-negative. MES were more strongly associated with cerebrovascular symptoms than with APS, antiphospholipid antibodies, or cardiac pathology. The time elapsed since the last ischemic cerebrovascular symptom was significantly shorter in microemboli-positive patients than in microemboli-negative patients (P |
| Databáze: | OpenAIRE |
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