Chemical analysis of norrisolide-induced Golgi vesiculation
| Autor: | Thomas P. Brady, Emmanuel A. Theodorakis, Gianni Guizzunti, Vivek Malhotra |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Golgi Apparatus
Kidney Biochemistry Catalysis Antibodies chemistry.chemical_compound symbols.namesake Colloid and Surface Chemistry Antibody Specificity Side chain Fluorescence microscope Animals Receptor Fluorescent Dyes Natural product Chemistry Biological activity General Chemistry Golgi apparatus Rats Microscopy Fluorescence Acetylation Biophysics symbols Diterpenes Intracellular |
| Zdroj: | Journal of the American Chemical Society. 128(13) |
| ISSN: | 0002-7863 |
| Popis: | The chemical origin of the norrisolide-induced irreversible Golgi vesiculation was studied using a variety of norrisolide probes. This natural product was found to bind to a receptor on the Golgi membranes using the perhydroindane core fragment as the recognition element. The acetylated gamma-lactol-gamma-lactone side chain of norrisolide is essential for the irreversible Golgi vesiculation and can be replaced by other electrophilic motifs without loss of biological function. In particular, compound 10 reproduces the cellular phenotype of the natural product. |
| Databáze: | OpenAIRE |
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