The effect of 12-month dehydroepiandrosterone supplementation on the menstrual pattern, ovarian reserve markers, and safety profile in women with premature ovarian insufficiency
| Autor: | Sofie Shuk Fei Yung, Queenie Ho Yan Wong, Jennifer K.Y. Ko, Hang Wun Raymond Li, Ernest Hung Yu Ng, Tracy Wing Yee Yeung |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Anti-Mullerian Hormone endocrine system Physiology Dehydroepiandrosterone Primary Ovarian Insufficiency Premature ovarian insufficiency 03 medical and health sciences Follicle-stimulating hormone 0302 clinical medicine Genetics Medicine Humans Testosterone Prospective Studies Ovarian reserve Ovarian Reserve Genetics (clinical) Menstrual Cycle 030219 obstetrics & reproductive medicine biology Estradiol business.industry Obstetrics and Gynecology Anti-Müllerian hormone General Medicine Antral follicle 030104 developmental biology Reproductive Physiology and Disease Reproductive Medicine biology.protein Female Liver function Follicle Stimulating Hormone business hormones hormone substitutes and hormone antagonists Biomarkers Developmental Biology |
| Zdroj: | Journal of assisted reproduction and genetics. 35(5) |
| ISSN: | 1573-7330 |
| Popis: | PURPOSE: To evaluate the effect of 12-month DHEA supplementation on menstrual pattern and ovarian reserve markers in women with premature ovarian insufficiency (POI) METHODS: This is a prospective observational study. Women with POI were given DHEA supplements (25 mg three times daily) for 12 months. Sonographic assessment for ovarian volume and antral follicle count (AFC) and serum measurement for anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), estradiol, testosterone, liver function, and hemoglobin level were performed at baseline and monthly for 13 months after the supplementation. Menstrual pattern, ovarian reserve markers, and side-effects were recorded. RESULTS: Between August 2011 and July 2014, 38 women with POI were recruited and 31 completed the study. The median age of women was 36 years, and the median baseline FSH and AMH concentrations were 82.2 IU/L and 0.01 ng/ml, respectively. No women had resumption of regular menstruation after DHEA supplementation. AMH, FSH, and AFC did not change significantly. No serious side effects were reported. CONCLUSIONS: Our results do not support any significant improvement in ovarian function by 12-month DHEA supplementation in women with POI. |
| Databáze: | OpenAIRE |
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