Efficacy of Atorvastatin in Prevention of Contrast-induced Nephropathy in High-risk Patients Undergoing Angiography: A Double-blind Randomized Controlled Trial
| Autor: | Maaz Hussain Syed, Vijay Thawani, Prakash Narayan Khandelwal, S S Katare |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Atorvastatin Contrast-induced nephropathy Urology 030204 cardiovascular system & hematology Group B law.invention Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Medicine Pharmacology (medical) Pharmacology Creatinine medicine.diagnostic_test business.industry medicine.disease N-acetylcysteine Surgery Contrast medium 030104 developmental biology chemistry contrast-induced nephropathy Angiography business medicine.drug Research Paper |
| Zdroj: | Journal of Pharmacology & Pharmacotherapeutics |
| ISSN: | 0976-500X |
| Popis: | Objective: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph. Materials and Methods: This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography. Results: A total of 160 patients completed the trial. Postprocedure, nine and two CIN cases were found in Group A and B, respectively. The mean change in serum creatinine was 0.086 ± 0.168 in Group A and 0.021 ± 0.083 in Group B, which was statistically significant (P = 0.0289). Postprocedure, the estimated glomerular filteration rate was reduced by 19.52 in Group A and 13.55 in Group B (P = 0.003). Conclusion: This trial indicates the positive role of statins in preventive strategy against CIN along with NAC. |
| Databáze: | OpenAIRE |
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