Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice
Autor: | Jee Hye Yun, Jung Un Lee, Jin Won Yang, Hee Kyung Yeo |
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Rok vydání: | 2019 |
Předmět: |
Curcumin
Steatosis Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Theracurmin 010501 environmental sciences Pharmacology Toxicology 030226 pharmacology & pharmacy 01 natural sciences Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fatty liver Nonalcoholic fatty liver disease medicine 0105 earth and related environmental sciences High fat diet (HFD) food and beverages Lipid metabolism medicine.disease Bioavailability chemistry Original Article Nonalcoholic fatty liver disease (NAFLD) |
Zdroj: | Toxicological Research |
ISSN: | 2234-2753 1976-8257 |
Popis: | Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, including antioxidant, anti-inflammatory, and chemo-preventive activities. Curcumin has been shown to have potential in preventing nonalcoholic fatty liver disease (NAFLD). However, the low bioavailability of curcumin has proven to be a major limiting factor in its clinical adoption. Theracurmin, a highly bioavailable curcumin that utilizes micronized technology showed improved biological absorbability in vivo. The aim of this study was to investigate the role of theracurmin in modulating hepatic lipid metabolism in vivo. A fatty liver mouse model was produced by feeding mice a high fat diet (HFD; 60% fat) for 12 weeks. We found that treatment for 12 weeks with theracurmin significantly lowered plasma triacylglycerol (TG) levels and reduced HFD-induced liver fat accumulation. Theracurmin treatment lowered hepatic TG and total cholesterol (T-CHO) levels in HFD-fed mice compared to controls. In addition, theracurmin administration significantly reduced lipid peroxidation and cellular damage caused by reactive oxygen species in HFD-fed mice. Overall, these results suggest that theracurmin has the ability to control lipid metabolism and can potentially serve as an effective therapeutic remedy for the prevention of fatty liver. |
Databáze: | OpenAIRE |
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