The Relationship between Phenazone (Antipyrine) Metabolite Formation and Theophylline Metabolism in Healthy and Frail Elderly Women
| Autor: | Horan Ma, Douwe D. Breimer, R.S. Gulati, E.J. Jansen, van Bezooijen Cf, Miljkovic B, Paramsothy, Groen K, Roberts Na |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Drug Aging medicine.medical_specialty Frail Elderly Health Status health care facilities manpower and services Metabolite media_common.quotation_subject Urinary system Phenazone chemistry.chemical_compound Theophylline Pharmacokinetics Internal medicine medicine Humans Pharmacology (medical) Chromatography High Pressure Liquid Aged media_common Aged 80 and over Pharmacology Metabolism Endocrinology chemistry Female Antipyrine Drug metabolism Half-Life medicine.drug |
| Zdroj: | Clinical Pharmacokinetics. 25:136-144 |
| ISSN: | 0312-5963 |
| Popis: | The influence of aging on the metabolism of phenazone (antipyrine), and the relationship between the formation of 3 phenazone metabolites and the metabolic clearance of theophylline in healthy and frail elderly women, were examined. Whereas the elimination half-life did not change, clearance of phenazone decreased by about 50% with age in healthy women receiving phenazone without theophylline. However, the summation of the urinary recovery of phenazone and the measured metabolites, expressed as percentage of the phenazone dose, was lower in the healthy elderly (37 +/- 9% vs 74 +/- 15%). In both healthy and frail females the clearance of formation of 4-hydroxy-phenazone and the metabolic clearance of theophylline correlated strongly (r = 0.93 and 0.90, respectively). In non-healthy elderly females, strong correlations were also observed between the other metabolic pathways of phenazone and the metabolic clearance of theophylline. Coadministration of theophylline in the elderly increased the percentage of the phenazone dose excreted as the measured metabolites. A considerably higher interindividual variability in the disposition of phenazone and theophylline was observed in the frail elderly women. This high degree of variability in drug metabolism may be one of the explanations for the problems often occurring after drug prescription in the elderly. |
| Databáze: | OpenAIRE |
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