Azithromycin and Glucosamine May Amplify the Type 1 Interferon Response to RNA Viruses in a Complementary Fashion
| Autor: | Mark F. McCarty, James J. DiNicolantonio, Jorge Barroso-Aranda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MDA5 Immunology Biology Azithromycin Antiviral Agents Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine RNA Virus Infections Glucosamine medicine Immunology and Allergy Animals Humans RNA Viruses Type 1 interferon azithromycin IRF-3 RNA type 1 interferon MAVS Virology 030104 developmental biology chemistry Host-Pathogen Interactions Interferon Type I glucosamine Drug Therapy Combination 030215 immunology medicine.drug |
| Zdroj: | Immunology Letters |
| ISSN: | 1879-0542 0165-2478 |
| Popis: | Highlights • Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. • O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP-N-acetylglucosamine. • Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may act synergistically to aid their control by enhancing type 1 interferon induction Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP-N-acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect