Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Autor: José Expósito, Jens Peter Bonde, José-Manuel Molina-Molina, Emilio Sánchez-Cantalejo, Mariana F. Fernández, Nicolás Olea, Elena Molina-Portillo, Maria Jose Sanchez-Perez, Piedad Martin-Olmedo, Juan P. Arrebola
Přispěvatelé: [Arrebola, JP, Expósito, J] Oncology Unit. Virgen de las Nieves University Hospital, Granada, Spain. [Fernández, MF, Olea, N] Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital. Granada, Spain.[Martín-Olmedo, P, Sánchez-Pérez, MJ, Sánchez-Cantalejo, E, Molina-Portillo, E] Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria de Granada, Granada, Spain. [Bonde, JP] Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, University of Copenhagen, Denmark, This study was supported in part by research grants from the Spanish Ministry of Health (FIS 02/974, EUS2008-03574), CIBER de Epidemiología, Junta de Andalucía (01/264, P09-CTS-5488 Project of Excellence, PI-0675-2010,and PI-0513-2012), and the Instituto de Salud Carlos III (FIS PI11/0610).
Rok vydání: 2014
Předmět:
Male
Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants [Medical Subject Headings]
Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Neoplasms
estudios prospectivos
Medicine
Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Follow-Up Studies [Medical Subject Headings]
Prospective cohort study
Waste Management and Disposal
Cancer
Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]
education.field_of_study
Follow-up
Incidence (epidemiology)
Persistent organic pollutants
Hazard ratio
Middle Aged
Diseases::Neoplasms [Medical Subject Headings]
Pollution
Anatomy::Tissues::Connective Tissue::Adipose Tissue [Medical Subject Headings]
Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings]
Adipose Tissue
Cohort
Regression Analysis
Environmental Pollutants
Estudios de seguimiento
Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings]
Adult
Tejido adiposo
Environmental Engineering
Population
Adipose tissue
Check Tags::Male [Medical Subject Headings]
Hazardous Substances
Environmental health
Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]
Humans
Environmental Chemistry
Prospective study
education
Contaminantes orgánicos
business.industry
Environmental Exposure
medicine.disease
Confidence interval
Cancer registry
Spain
Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Hazardous Substances [Medical Subject Headings]
business
Follow-Up Studies
Zdroj: Digibug. Repositorio Institucional de la Universidad de Granada
instname
ISSN: 0048-9697
DOI: 10.1016/j.scitotenv.2014.08.043
Popis: There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01–1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.
This study was supported in part by research grants from the Spanish Ministry of Health (FIS 02/974, EUS2008-03574), CIBER de Epidemiología; Junta de Andalucía (01/264, P09-CTS-5488 Project of Excellence, PI-0675-2010, and PI-0513-2012), and the Instituto de Salud Carlos III (FIS PI11/0610).
Databáze: OpenAIRE
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