Proinflammatory and anti-inflammatory biomarkers in schizophrenia and influence of simvastatin on the interleukin-6
| Autor: | Raquel Veronica Jacobus, Iarsan Ardeola Salah, Victor Hugo Schaly Cordova, Lenise Petter Francesconi, Keila Maria Mendes Ceresér, Paulo Belmonte-de-Abreu, Larissa F. de Oliveira, André Tavares Victorino, Eduarda Dias da Rosa |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Simvastatin medicine.medical_specialty medicine.drug_class Anti-Inflammatory Agents Inflammation Gastroenterology Anti-inflammatory Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Pharmacology (medical) Interleukin 6 biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Case-control study Middle Aged medicine.disease Interleukin-12 Interleukin-10 030227 psychiatry Psychiatry and Mental health Schizophrenia Case-Control Studies biology.protein Female Tumor necrosis factor alpha medicine.symptom business Biomarkers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | International Clinical Psychopharmacology. 34:84-88 |
| ISSN: | 0268-1315 |
| DOI: | 10.1097/yic.0000000000000241 |
| Popis: | The present study sought to assess biomarkers of inflammation in stable patients with schizophrenia (SZ) on clozapine therapy. We recruited 60 outpatients with SZ and 60 healthy controls, matched for sex and age. Compared with controls, patients had significantly increased concentrations of interleukin-6 and tumor necrosis factor-α. Interestingly, patients on simvastatin had lower interleukin-6 levels compared with patients not on simvastatin and controls. This study corroborated previous evidence for increased inflammatory biomarkers in SZ and detected a potential anti-inflammatory action of simvastatin in patients with a clinical diagnosis of SZ on clozapine therapy. |
| Databáze: | OpenAIRE |
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