Clinical usefulness of high levels of C-reactive protein for diagnosing epithelial ovarian cancer

Autor:	Zongtao Liu, Desheng Yang, Haini Li, Xiaoyan Sun, Shengmei Yang, Kewei Wang
Rok vydání:	2020
Předmět:	Oncology medicine.medical_specialty endocrine system diseases lcsh:Medicine Article Medical research Internal medicine Biomarkers Tumor Medicine Humans Epithelial ovarian cancer Stage (cooking) lcsh:Science Cancer Ovarian Neoplasms Multidisciplinary Tumor size Receiver operating characteristic biology business.industry C-reactive protein lcsh:R Area under the curve Middle Aged medicine.disease Prognosis Adenocarcinoma Mucinous female genital diseases and pregnancy complications Cystadenocarcinoma Serous Endometrial Neoplasms C-Reactive Protein ROC Curve Risk factors Case-Control Studies biology.protein lcsh:Q Female business Ovarian cancer Biomarkers
Zdroj:	Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
ISSN:	2045-2322
Popis:	The purpose of the present study was to evaluate the diagnostic role of CRP in ovarian cancer and to assess whether CRP can be combined with tumor markers to enhance the diagnostic efficacy toward ovarian cancer. Area under the curve, sensitivity, and specificity were calculated to access the diagnostic ability of each singly and combined as markers for ovarian cancer. The CRP cut-off value was then calculated to evaluate the diagnostic efficacy of CRP for ovarian cancer. Our results showed that values for all markers were significantly higher in the cancer group than in the control group. Receiver operating characteristic curve results showed that CA125 had the highest diagnostic efficacy for ovarian cancer, while the sensitivity for CRP was higher than for CA125, and the specificity for CRP was equal to that of CA125. The combination of CRP, CA125, and HE4, however, provided the strongest diagnostic capability. Furthermore, the diagnostic cut-off value for CRP with regard to ovarian cancer was 9.8 mg/L, and high levels of CRP were correlated with stage and tumor size of ovarian cancer. Our study indicated that CRP is valuable in the diagnosis of ovarian cancer, and that combining CRP with CA125 and HE4 improved the diagnostic efficacy with respect to ovarian cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1ef730fbc9334939ebd0b0164752b0 https://pubmed.ncbi.nlm.nih.gov/33208875 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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