In vitro activity of 4'-iodo-4'-deoxydoxorubicin on human colo-rectal cancer as measured by a short-term antimetabolic assay
| Autor: | Fernando Giuliani, O. Sanfilippo, Giovanni Colella, Rosella Silvestrini, Nadia Zaffaroni, Raffaella Villa |
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| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
Anthracycline 4'-iodo-4'-deoxydoxorubicin Rectum Colo-rectal cancer Biology medicine.disease In vitro medicine.anatomical_structure Oncology Doxorubicin Immunology Carcinoma medicine Tumor Cells Cultured Humans Pharmacology (medical) Cytotoxicity Colorectal Neoplasms Uridine medicine.drug Thymidine |
| Zdroj: | Investigational new drugs. 8(2) |
| ISSN: | 0167-6997 |
| Popis: | A short-term antimetabolic assay based upon the inhibition of incorporation of nucleic acid precursors was used to compare the cytotoxicity of a new halogenated anthracycline, 4′-iodo-4′-deoxydoxorubicin (IDX), with that of its parent compound doxorubicin (DX) on human colo-rectal carcinoma specimens. IDX showed a marked dose-dependent effect, with frequencies of activity consistently greater than those of DX at all concentrations. The minimal dose required to induce a significant antimetabolic effect for IDX was 1/10 that for DX. |
| Databáze: | OpenAIRE |
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