Synthesis of silicon-containing azole derivatives with magnesium bromide diethyl etherate, and an investigation of their fungicidal activities

Autor:	Hisaki Kajino, Hideo Takeshiba, Takahiro Tsukiyama, Junzo Tobitsuka, Hiroyuki Itoh, Yukiyoshi Takahi, Mikio Tsuda, Hiroshi Ohta
Rok vydání:	2002
Předmět:	Azoles Antifungal Agents Clinical Biochemistry Pharmaceutical Science Ether Biochemistry Chloride Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Magnesium bromide Organometallic Compounds medicine Structure–activity relationship Organic chemistry Molecular Biology Plant Diseases chemistry.chemical_classification Addition reaction Silicon Compounds Organic Chemistry Fungi Fungicides Industrial chemistry Herbicide safener Food Microbiology Molecular Medicine Azole Indicators and Reagents Phytotoxicity medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry. 10:4029-4034
ISSN:	0968-0896
Popis:	Enhancement of magnesium bromide diethyl etherate in addition reaction of trimethylsilylmethylmagnesium chloride 5 to 2-(1H-1,2,4-triazol-1-yl)acetophenones 6 allowed us to prepare silicon-containing azole derivatives, which were tested for fungicidal activity and phytotoxicity. Among them, 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpropan-2-ol 1a was determined to be the most effective and potential candidate for novel fungicide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1bdce88e05de329115d061934a2969 https://doi.org/10.1016/s0968-0896(02)00302-4 Zobrazit plný text záznamu Full Text from ScienceDirect