Self‐Assembly of Disorazole C1 through a One‐Pot Alkyne Metathesis Homodimerization Strategy†
Autor: | Kevin J. Ralston, H. Clinton Ramstadius, Richard C. Brewster, Helen S. Niblock, Alison N. Hulme |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: | |
Zdroj: | Angewandte Chemie (Weinheim an Der Bergstrasse, Germany) |
ISSN: | 1521-3757 0044-8249 |
Popis: | Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C2‐symmetric marine‐derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process. |
Databáze: | OpenAIRE |
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