Self‐Assembly of Disorazole C1 through a One‐Pot Alkyne Metathesis Homodimerization Strategy†

Autor:	Kevin J. Ralston, H. Clinton Ramstadius, Richard C. Brewster, Helen S. Niblock, Alison N. Hulme
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Naturstoffe 010405 organic chemistry Zelltoxizität Alkinmetathese General Medicine Zuschriften Selbstorganisation 010402 general chemistry 01 natural sciences Zuschrift Totalsynthese 0104 chemical sciences Alkinmetathese | Hot Paper
Zdroj:	Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)
ISSN:	1521-3757 0044-8249
Popis:	Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C2‐symmetric marine‐derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1ba4c107916227d2c1c5b4d9cb92bc http://europepmc.org/articles/PMC4902119 Zobrazit plný text záznamu Plný text ve formátu PDF