Systemic response of coated-platelet and peripheral blood inflammatory cell indices after aneurysmal subarachnoid hemorrhage and long-term clinical outcome
| Autor: | Claire Delpirou Nouh, Faranak Aghaei, Calin I. Prodan, Lance Ford, Stephen R. Ross, George L. Dale, Kimberly Hollabaugh, Gopichand Danala, Bin Zheng, Bappaditya Ray, Brittany N. Karfonta, Joshua A. Santucci, Bradley N. Bohnstedt, Benjamin O. Cornwell |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Subarachnoid hemorrhage Lymphocyte Ischemia Critical Care and Intensive Care Medicine Gastroenterology Article Brain Ischemia Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Platelet Lymphocytes Prospective Studies Mean platelet volume Prospective cohort study Aged Retrospective Studies Inflammation Platelet Count business.industry Montreal Cognitive Assessment 030208 emergency & critical care medicine Middle Aged Subarachnoid Hemorrhage medicine.disease Aneurysm Peripheral Treatment Outcome medicine.anatomical_structure 030228 respiratory system Regression Analysis Female business Mean Platelet Volume Biomarkers |
| Zdroj: | J Crit Care |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2019.03.003 |
| Popis: | PURPOSE: Post-hemorrhage period after aneurysmal subarachnoid hemorrhage (aSAH) has several systemic manifestations including prothrombotic and pro-inflammatory states. Inter-relationship between these states using established/routine laboratory biomarkers and its long-term effect on clinical outcome is not well-defined. MATERIALS AND METHODS: Retrospective analysis of prospective cohort of 44 aSAH patients. Trend of procoagulant biomarkers [coated-platelets, mean platelet volume to platelet count (MPV:PLT)] and peripheral inflammatory biomarkers [platelet-lymphocyte ratio (PLR), neutrophil-platelet ratio (NLR)] were analyzed using regression analysis. Occurrence of delayed cerebral ischemia (DCI), modified Rankin score (mRS) of 3–6 and Montreal cognitive assessment (MoCA) of |
| Databáze: | OpenAIRE |
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