| Autor: |
Chen, X.B., Yang, H., Song, X., Liang, H., Wei, Y., Lu, J., Barz, M., Jin, R.R., Nie, Y. |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Chinese Chemical Letters, 34(5):107753. ELSEVIER SCIENCE INC |
| Popis: |
The integrated lipopeptide (RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment. After self-assembling and target coating modification, the poly(gamma-glutamic acid) (gamma-PGA)/RVA nano-vectors can sequentially respond to pH & redox stimuli, and guarantee efficient therapeutic gene delivery and control release of all -trans retinoic acid. The design provides a facile but promising strategy to treat refractory cancers.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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