De Novo Infection of B Cells during Murine Gammaherpesvirus 68 Latency
| Autor: | David L. Woodland, Michael L. Freeman, Claire E. Burkum, Marcia A. Blackman, Eric J. Yager |
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| Rok vydání: | 2011 |
| Předmět: |
Rhadinovirus
T-Lymphocytes viruses Immunology Murine gammaherpesvirus 68 Biology Antibodies Viral Microbiology Lymphocyte Depletion Virus Mice Mice Congenic Immune system In vivo Virology Animals Latency (engineering) B-Lymphocytes Viral reactivation Viral Load Virus Internalization Virus Latency Insect Science biology.protein Pathogenesis and Immunity Virus Activation Antibody Viral load |
| Zdroj: | Journal of Virology. 85:10920-10925 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | The mechanisms by which gammaherpesviruses maintain latency are unclear. Here we used a murine gammaherpesvirus model to show that previously uninfected B cells in immunocompetent mice can acquire virus during latency. In vivo depletion of T cells allowed viral reactivation, as measured by increased viral loads, but not enhanced transfer of virus to new cells. In the absence of both immune T cells and antibody following the transfer of latently infected cells into naïve animals, there was robust infection of new B cells. These data confirm that both T cells and antibody contribute to the control of gammaherpesvirus latency, reactivation, and spread. |
| Databáze: | OpenAIRE |
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