2-Diphenylphosphanyl-4-pyridyl(dimethyl)amine as an effective ligand for the ruthenium(II) complex catalyzed homogeneous hydration of nitriles under neutral conditions

Autor:	Toshiyuki Oshiki, Wataru Okumura, Makoto Muranaka, Isao Hyodo
Rok vydání:	2011
Předmět:	Nitrile Hydration chemistry.chemical_element Homogeneous catalysis General Chemistry Amides Medicinal chemistry Ruthenium Catalysis chemistry.chemical_compound chemistry Amide Organic chemistry Moiety Amine gas treating Phosphine
Zdroj:	Catalysis Today. 164:552-555
ISSN:	0920-5861
Popis:	New homogeneous catalyst comprised of [Ru(methallyl)(2)(cod)] (cod = 1,5-cyclooctadiene) (1) and 2-diphenylphosphanyl-4-pyridyl(dimethyl) amine (2) is shown to efficiently catalyze the hydration of various nitriles under neutral conditions. The hydration proceeds in the presence of 0.5 mol% of the ruthenium catalyst at 80 degrees C in 1,2-dimethoxyethane solution and the corresponding amide is obtained within few hours without the formation of by products. Comparison of some phosphine ligands for the hydration reveals that the dimethylamino moiety of 2 improves the catalytic performance dramatically.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b14a00cd82e9c658fe52326da93e799 https://doi.org/10.1016/j.cattod.2010.11.050 Zobrazit plný text záznamu Full Text from ScienceDirect