Serum soluble urokinase plasminogen activator receptor as a potential biomarker of renal impairment severity in diabetic nephropathy
| Autor: | Ioana Ailincăi, Gabriela Lupușoru, Andreea Andronesi, Dana Manda, Bogdan Sorohan, Gener Ismail, Georgia Micu, Mircea Lupușoru, Camelia Achim, Andra Caragheorgheopol |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Renal function Gastroenterology Receptors Urokinase Plasminogen Activator Diabetic nephropathy Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Diabetes Mellitus Humans Diabetic Nephropathies Proteinuria business.industry General Medicine Diabetic retinopathy medicine.disease Cross-Sectional Studies SuPAR Albuminuria medicine.symptom business Biomarkers Kidney disease |
| Zdroj: | Diabetes research and clinical practice. 182 |
| ISSN: | 1872-8227 |
| Popis: | Aims To investigate serum soluble form of urokinase-type plasminogen activator receptor (suPAR) in patients with diabetic kidney disease (DKD) and biopsy-proven diabetic nephropathy (DN), its correlation with histological parameters and its capacity as a biomarker for renal impairment severity. Methods We conducted a cross-sectional study on 75 patients with diabetes mellitus (DM) and DKD, among whom 28 had biopsy-proven DN. Results Among the 75 patients, 9 (12%) had type 1 and 66 (88%) type 2 DM. The median value of the serum suPAR level was 2857.2 pg/mL (1916.4–3700) in the entire cohort and 2472.1 pg/mL (1782.6–3745.8) in the biopsy-proven DN subgroup, respectively. suPAR was significantly correlated with diabetes duration, diabetic retinopathy, anti-proteinuric treatment, albuminuria, kidney function, DN class, interstitial fibrosis and tubular atrophy (IFTA) score and with interstitial inflammation score. suPAR had a good accuracy for the association with chronic kidney disease (CKD) stages G3b-5, macroalbuminuria, DN class IV, IFTA score 3 and interstitial inflammation score 2. Conclusions Serum suPAR was increased in DN patients and was associated with DM duration, diabetic retinopathy, renoprotective treatment, kidney function, proteinuria, DN class, IFTA and interstitial inflammation scores. Also, suPAR had a good capacity as a biomarker for advanced renal impairment and severe histological lesions of DN. |
| Databáze: | OpenAIRE |
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