Exclusion testing in pregnancy for Huntington's disease
| Autor: | Peter S. Harper, L. P. Lazarou, O. W. J. Quarrell, Albert Tyler, A. L. Meredith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Genetic counseling Genetic Counseling Disease Huntington's disease Pregnancy Genetics medicine Presymptomatic Testing Humans Genetic Testing Predictive testing Genetics (clinical) Genetic testing medicine.diagnostic_test Middle Aged Patient Acceptance of Health Care medicine.disease Test (assessment) Huntington Disease Chorionic Villi Sampling Family medicine Female Psychology DNA Probes Research Article |
| Popis: | The results of DNA analysis are presented for a series of 90 couples, with one partner at 50% risk for Huntington's disease (HD), who were referred for exclusion testing in pregnancy over a three year period. Thirty-seven couples were studied in detail. The aims of the study were to evaluate attitudes towards prenatal testing, before pregnancy and afterwards, and the effectiveness of our counseling and methods of organising the service. Problems which could arise in relation to presymptomatic testing are documented. It is concluded that exclusion testing is a valuable form of prediction for some couples, particularly where family structure does not permit prediction for the person at risk. The need for intensive counselling was highlighted by the difficulties experienced by many couples in understanding how the test worked. Particular ethical and organisational problems may arise which require careful consideration beforehand and some recommendations are made. The proportion of couples who will continue to request exclusion testing as pre-symptomatic testing becomes more widely applicable remains unknown. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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