Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation
| Autor: | Fabrice Pierre, Paule Latino-Martel, Serge Hercberg, Valentin Partula, Abou Diallo, Mathilde Touvier, Bernard Srour, Pilar Galan, Philippine Fassier, Mélanie Deschasaux, Françoise Guéraud |
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| Přispěvatelé: | Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Public Health Department, Réseau National Alimentation Cancer Recherche (réseau NACRe), Prévention et promotion de la cancérogénèse par les aliments (ToxAlim-PPCA), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Canceropole Ile-de-France (public funding from the Paris region), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), Institut National de la Recherche Agronomique (INRA) - Université Paris Diderot - Paris 7 (UPD7) - Université Paris Descartes - Paris 5 (UPD5) - Université Paris 13 - Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National Polytechnique [Toulouse] (INP) - Institut National de la Recherche Agronomique (INRA) - Université Paul Sabatier - Toulouse 3 (UPS) - Ecole Nationale Vétérinaire de Toulouse, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), ProdInra, Archive Ouverte, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Deschasaux, Mélanie |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Pathology Antioxidant medicine.medical_treatment [SDV]Life Sciences [q-bio] Iron Physiology Breast Neoplasms Placebo mammary malignant tumor human health Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer breast cancer Epidemiology medicine Humans dietary iron antioxidants lipid peroxidation prospective study Prospective Studies Prospective cohort study métabolisme du fer Aged Dietary iron business.industry Proportional hazards model peroxydation lipidique cancer du sein santé humaine Middle Aged medicine.disease 3. Good health [SDV] Life Sciences [q-bio] 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Dietary Supplements Female business Research Paper |
| Zdroj: | Oncotarget Oncotarget, Impact journals, 2016, 7 (48), pp.78994-79002. ⟨10.18632/oncotarget.12592⟩ Oncotarget, Impact journals, 2016, 7 (48), pp.78994-79002. 〈10.18632/oncotarget.12592〉 Oncotarget, 2016, 7 (48), pp.78994-79002. ⟨10.18632/oncotarget.12592⟩ Oncotarget 48 (7), 78994-79002. (2016) |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.12592⟩ |
| Popis: | Experimental results suggested that iron-induced lipid peroxidation may explain the direct associations observed between red/processed meat intakes and colorectal and breast cancer risk. However, epidemiological evidence is lacking. Thus, we investigated the association between dietary iron intake and breast cancer risk, and its potential modulation by an antioxidant supplementation and lipid intake. This prospective study included 4646 women from the SU. VI. MAX trial (daily lowdose antioxidants vs. placebo). 188 incident breast cancers were diagnosed (median follow-up= 12.6y). Dietary iron intake was assessed using repeated 24h dietary records. Multivariable Cox proportional hazards models were computed. Dietary iron intake was associated with an increased breast cancer risk (HRT3vs. T1= 1.67 (1.022.71), P-trend= 0.04). This association was observed in the placebo group (HRT3vs. (T1)= 2.80 (1.42-5.54), P-trend= 0.003), but not in the antioxidant-supplemented group (P-trend= 0.7, P-interaction= 0.1). Besides, in the placebo group, the increased breast cancer risk associated with dietary iron intake was more specifically observed in women with higher lipid intake (P-trend= 0.046). These findings suggest that dietary iron intake may be associated with an increased breast cancer risk, especially in women who did not received antioxidants during the trial and who consumed more lipids. This supports the experimental results suggesting that breast cancer risk may be increased by iron-induced lipid peroxidation. |
| Databáze: | OpenAIRE |
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