TH17-phenotypes of juvenile idiopathic arthritis
| Autor: | G. Novik, Natalia V Bychkova, Inga Z Turtsevich |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Chemokine
biology business.industry medicine.medical_treatment Cartilage Arthritis medicine.disease_cause medicine.disease Autoimmunity Proinflammatory cytokine Cytokine medicine.anatomical_structure Rheumatology Pediatrics Perinatology and Child Health Immunology Poster Presentation medicine biology.protein Immunology and Allergy Tumor necrosis factor alpha Pediatrics Perinatology and Child Health business Infiltration (medical) |
| Zdroj: | Pediatric Rheumatology Online Journal |
| ISSN: | 1546-0096 |
| Popis: | Juvenile idiopathic arthritis (JIA) is a chronic disorder with unknown etiology and characterized by autoimmunity, infiltration of synovium by activated proinflammatory cells, synovial hyperplasia and progressive destruction of cartilage and bone. IL-17A is a proinflammatory cytokine that is expressed in the inflamed synovium. Th17 cells have been identified as main producers of this cytokine. IL-17A is a potent inducer of various cytokines and chemokines. In addition, this cytokine has been shown to have additive or even synergistic effects with TNFα and IL-1β on cytokine induction and tissue destruction. |
| Databáze: | OpenAIRE |
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