IgG subclass response toHelicobacter pyloriand CagA antigens in children
| Autor: | M. Raeiszadeh, Danuta Celinska-Cedro, Jean E. Crabtree, Danuta Dzierzanowska, Katarzyna Dzierżanowska-Fangrat, M. Gladkowska-Dura |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Adolescent Spirillaceae Immunology Enzyme-Linked Immunosorbent Assay Biology digestive system Statistics Nonparametric Subclass Helicobacter Infections Microbiology Immune system Bacterial Proteins Antigen Clinical Studies Humans Immunology and Allergy CagA Child Analysis of Variance Antigens Bacterial Helicobacter pylori bacterial infections and mycoses biology.organism_classification digestive system diseases Duodenal Ulcer Gastritis Immunoglobulin G Humoral immunity biology.protein Female Antibody |
| Zdroj: | Clinical and Experimental Immunology. 134:442-446 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2003.02304.x |
| Popis: | SUMMARYSpecific serum IgG subclass antibodies against Helicobacter pylori antigens and recombinant CagA were analysed in 75 symptomatic children with histologically confirmed H. pylori infection. H. pylori stimulated an IgG1 predominant response, and IgG3 titres showed a positive association with peptic ulcer disease, chronicity of antral inflammation and density of H. pylori colonization. Two methods used for assessing serum IgG CagA antibody status, i.e. Western blotting and enzyme-linked immunosorbent assay (ELISA), were concordant. CagA stimulated an IgG1 and IgG3 predominant humoral response. Total CagA IgG titres were higher in children with active and more severe chronic antral inflammation. These findings suggest that in children the systemic humoral immune response to H. pylori infection may reflect gastroduodenal pathology. |
| Databáze: | OpenAIRE |
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