Antibacterial properties of nitric oxide–releasing sol‐gels
| Autor: | Brian J. Nablo, Mark H. Schoenfisch |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Materials science
Cell Survival Surface Properties medicine.medical_treatment Biomedical Engineering Nitric Oxide medicine.disease_cause Bacterial Adhesion Nitric oxide Microbiology Biomaterials Contact angle chemistry.chemical_compound medicine Saline Antibacterial agent Sol-gel Molecular Structure Pseudomonas aeruginosa Silicon Compounds Metals and Alloys Water Adhesion Controlled release Anti-Bacterial Agents chemistry Ceramics and Composites Azo Compounds Gels Nuclear chemistry |
| Zdroj: | Journal of Biomedical Materials Research Part A. :1276-1283 |
| ISSN: | 1552-4965 1549-3296 |
| DOI: | 10.1002/jbm.a.20030 |
| Popis: | The antibacterial characteristics of nitric oxide (NO)-releasing sol-gel coatings are described. The NO release from these surfaces is steady over short periods (approximately 1 h) and measurable over several days. The ability of NO to prevent bacterial adhesion is evaluated by exposing controls and NO-releasing sol-gels to approximately 10(8) colony-forming units (cfu)/mL saline suspensions of Pseudomonas aeruginosa. Pseudomonas aeruginosa adhesion to sol-gel controls varies depending on the sol-gel formulation. Sol-gel surfaces capable of NO release decrease bacterial adhesion by 30% to 95% relative to controls. The contact angle measurements of control and NO-releasing surfaces are similar, supporting NO's action as an antibacterial agent against bacterial adhesion. |
| Databáze: | OpenAIRE |
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