Surgical treatment of breast cancer in patients aged 80 years or older – how much is enough?
| Autor: | Barbara Perić, Radan Dzodic, Rok Petric, Gasper Pilko, Hana Besic, Jan Zmuc, Nikola Besic, Andraz Perhavec |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Cancer Research Axillary lymph nodes medicine.medical_treatment Sentinel lymph node Population Breast Neoplasms Mastectomy Segmental Breast cancer Elderly Surgical oncology Genetics Medicine Humans skin and connective tissue diseases education Neoplasm Staging Retrospective Studies Aged 80 and over education.field_of_study business.industry Sentinel Lymph Node Biopsy Age Factors Cancer medicine.disease Prognosis Surgery Treatment medicine.anatomical_structure Oncology Female Neoplasm Grading business Quadrantectomy Mastectomy Research Article |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-14-700 |
| Popis: | Background The population of elderly people is increasing and so is the population of breast cancer patients aged ≥80 years. The aim of our retrospective study was to identify independent prognostic factors for the duration of breast cancer-specific survival of surgically treated patients aged ≥80 years. The secondary aim was to determine the appropriate surgical treatment of breast cancer in patients aged ≥80 years. Methods We reviewed the medical records of 154 patients aged ≥80 years with early-stage breast cancer (mean age 83 years) who underwent surgery at the tertiary cancer center in the period from 2000 to 2008. Tumor stage was pT1/pT2 and pT3/pT4 in 75% and 25%, respectively. Surgical treatment comprised: quadrantectomy (in 27%), mastectomy (in 73%), axillary dissection (in 57%), and sentinel lymph node biopsy (in 18%), while 25% of patients had no axillary surgery. Results During a median follow-up of 5.3 years, 31% of patients died of breast cancer, while 28% of patients died of other causes. Half of our patients with poorly differentiated breast cancer or estrogen receptor-negative tumor died of breast cancer. Multivariate statistical analysis showed that the pathological T-stage, pathological N-stage and estrogen receptors were independent prognostic factors for the duration of breast cancer-specific survival of patients. Conclusion Short breast cancer-specific survival indicates that, in patients aged ≥80 years, breast cancer with metastases in axillary lymph nodes can be an aggressive disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|