Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis
| Autor: | Lisa Richards, Jeffrey Cui, H. Aryafar, Jonathan Hooker, Phirum Nguyen, Rohit Loomba, Ricki Bettencourt, Archana Bhatt, Catherine A. Hooker, Mark A. Valasek, Janki Patel, William Haufe, Joanie Salotti, Carolyn Hernandez, Claude B. Sirlin |
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| Rok vydání: | 2016 |
| Předmět: |
Nonalcoholic steatohepatitis
nonalcoholic fatty liver disease Pathology medicine.medical_specialty magnetic resonance imaging (MRI) Clinical Trials and Supportive Activities Chronic Liver Disease and Cirrhosis Clinical Sciences Histological response Oral and gastrointestinal 030218 nuclear medicine & medical imaging Hepatitis 03 medical and health sciences 0302 clinical medicine Clinical Research Nonalcoholic fatty liver disease Liver fat medicine magnetic resonance imaging lcsh:RC799-869 nonalcoholic steatohepatitis Original Research medicine.diagnostic_test fat mapping business.industry Liver Disease MRI-proton-density-fat-fraction (PDFF) Gastroenterology Magnetic resonance imaging Pharmacology and Pharmaceutical Sciences medicine.disease Advanced fibrosis MRI-proton-density-fat-fraction advanced fibrosis noninvasive assessment Biomarker (medicine) biomarker Biomedical Imaging lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Steatosis business Digestive Diseases |
| Zdroj: | Therapeutic advances in gastroenterology, vol 9, iss 5 Patel, J; Bettencourt, R; Cui, J; Salotti, J; Hooker, J; Bhatt, A; et al.(2016). Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 9(5), 692-701. doi: 10.1177/1756283X16656735. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7s60013q Therapeutic Advances in Gastroenterology, Vol 9 (2016) |
| DOI: | 10.1177/1756283X16656735. |
| Popis: | Background: Magnetic resonance imaging-estimated proton-density-fat-fraction (MRI-PDFF) has been shown to be a noninvasive, accurate and reproducible imaging-based biomarker for assessing steatosis and treatment response in nonalcoholic steatohepatitis (NASH) clinical trials. However, there are no data on the magnitude of MRI-PDFF reduction corresponding to histologic response in the setting of a NASH clinical trial. The aim of this study was to quantitatively compare the magnitude of MRI-PDFF reduction between histologic responders versus histologic nonresponders in NASH patients. Methods: This study is a secondary analysis of the MOZART trial, which included 50 patients with biopsy-proven NASH randomized to ezetimibe 10 mg/day orally or placebo for 24 weeks. The primary aim was to perform a head-to-head comparative analysis of histologic responders [defined as a ⩾2-point reduction in the nonalcoholic fatty liver disease (NAFLD) Activity Score (NAS) without worsening fibrosis] versus nonresponders, and the corresponding quantitative change in liver fat content measured via MRI-PDFF. Results: Of the 35 patients who underwent paired liver biopsy and MRI-PDFF assessment at the beginning and end of treatment, 10 demonstrated a histologic response. Compared with histologic nonresponders, histologic responders had a statistically significant reduction in MRI-PDFF of −4.1% ± 4.9 versus −0.6 ± 4.1 ( p < 0.04) with a mean relative percent change of −29.3% ± 33.0 versus +2.0% ± 24.0 ( p < 0.004), respectively. Conclusions: Utilizing paired MRI-PDFF and liver histology data, we demonstrate that a relative reduction of 29% in liver fat on MRI-PDFF is associated with a histologic response in NASH. After external validation by independent research groups, these results can be incorporated into designing future NASH clinical trials, especially those utilizing change in hepatic fat quantified by MRI-PDFF, as a treatment endpoint. |
| Databáze: | OpenAIRE |
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