Latent Gene Sequencing Reveals Familial Relationships among Chinese Epstein-Barr Virus Strains and Evidence for Positive Selection of A11 Epitope Changes
| Autor: | Alan B. Rickinson, R Midgley, Andrew I. Bell, Duncan J. McGeoch |
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| Rok vydání: | 2003 |
| Předmět: |
China
Herpesvirus 4 Human Sequence analysis Immunology Epitopes T-Lymphocyte Locus (genetics) Biology Microbiology DNA sequencing Epitope HLA-A11 Antigen Conserved sequence Genetic drift Virology Genetic variation Humans Amino Acid Sequence Selection Genetic Gene Conserved Sequence Genetics Polymorphism Genetic HLA-A Antigens Computational Biology Genetic Variation Sequence Analysis DNA Virus Latency Epstein-Barr Virus Nuclear Antigens Insect Science Recombination and Evolution T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of Virology. 77:11517-11530 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.77.21.11517-11530.2003 |
| Popis: | Epstein-Barr virus (EBV) strains from the highly HLA-A11-positive Chinese population are predominantly type 1 and show a variety of sequence changes (relative to the contemporary Caucasian prototype strain B95.8) in the nuclear antigen EBNA3B sequences encoding two immunodominant HLA-A11 epitopes, here called IVT and AVF. This has been interpreted by some as evidence of immune selection and by others as random genetic drift. To study epitope variation in a broader genomic context, we sequenced the whole of EBNA3B and parts of the EBNA2, 3A, and 3C genes from each of 31 Chinese EBV isolates. At each locus, type 1 viruses showed |
| Databáze: | OpenAIRE |
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