Whole-grain consumption and its effects on hepatic steatosis and liver enzymes in patients with non-alcoholic fatty liver disease: a randomised controlled clinical trial
| Autor: | Ali Jafary Heidarloo, Masoumeh Dorosti, Mohammad Alizadeh, Farnush Bakhshimoghaddam |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Medicine (miscellaneous) 030209 endocrinology & metabolism Gastroenterology Metabolic equivalent Eating 03 medical and health sciences 0302 clinical medicine Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Aspartate Aminotransferases Whole Grains 030109 nutrition & dietetics Nutrition and Dietetics medicine.diagnostic_test business.industry Fatty liver Alanine Transaminase gamma-Glutamyltransferase Middle Aged Anthropometry medicine.disease Clinical trial Treatment Outcome Blood pressure Liver Female Steatosis Edible Grain Lipid profile business |
| Zdroj: | British Journal of Nutrition. 123:328-336 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) is a considerable challenge to public health across the globe. Whole grain is highly recommended as an inseparable part of a healthy diet and has been proposed as an effective way to manage NAFLD. The objective in the present study was to evaluate the effects of whole-grain consumption on hepatic steatosis and liver enzymes as primary outcomes in patients with NAFLD. Over the 12 weeks of this open-label, randomised controlled clinical trial, 112 patients (mean age 43 (sd 8·7) years; BMI 32·2 (sd 4·3) kg/m2) were randomly assigned to two groups to receive dietary advice, either to obtain at least half of their cereal servings each day from whole-grain foods or from usual cereals. By the end of the study, the grades of NAFLD showed a significant decrease in the intervention group (P < 0·001). In addition, a significant reduction in serum concentration of alanine aminotransferase (P < 0·001), aspartate aminotransferase (P < 0·001), γ-glutamyltransferase (P = 0·009), systolic blood pressure (P = 0·004) and diastolic blood pressure (P = 0·008) was observed in the intervention group compared with the control group. After adjusting, however, no significant differences were found between the two groups in terms of lipid profile, glycaemic status and anthropometric measurements. Overall, our study demonstrated that consumption of whole grains for 12 weeks had beneficial effects on hepatic steatosis and liver enzymes concentrations in patients with NAFLD. |
| Databáze: | OpenAIRE |
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