Synthetic sulfated glucuronosyl paragloboside (SGPG) and its use for the detection of autoimmune peripheral neuropathies

Autor:	Carlos Afonso, Benoit Colsch, Nicole Baumann, Jean-Claude Tabet, Reynald Chevalier, Jean-Maurice Mallet
Rok vydání:	2006
Předmět:	Chemistry Electrospray mass spectrometry Organic Chemistry General Medicine Mass spectrometry Biochemistry Peripheral Glycolipid medicine.anatomical_structure Sulfation Peripheral nerve Peripheral nervous system Drug Discovery medicine
Zdroj:	Tetrahedron. 62:563-577
ISSN:	0040-4020
Popis:	The sulfated glucuronosyl paragloboside SO4-3-GlcA(β1-3)Gal-(β1-4)GlcNAc(β1-3)Gal-(β1-4)Glcβ(1-1′)Cer (SGPG) is a specific constituent of the peripheral nervous system involved in human dysimmune neuropathies. Although it is highly immunogenic in human pathology, it is not a major constituent of peripheral nerve in humans. Pure SGPG is very difficult to obtain from natural sources, but is needed for the design of efficient and reproducible immunoassays. We describe a new chemical synthesis of this important glycolipid with a stearic tail, including its complete characterization by mass spectrometry and its use in the detection of autoimmune neuropathies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b09e834592117d82975a8da0faee8ff https://doi.org/10.1016/j.tet.2005.10.021 Zobrazit plný text záznamu Full Text from ScienceDirect