Effect of six-month lifestyle intervention on adiponectin, resistin and soluble tumor necrosis factor-α receptors in obese adolescents
| Autor: | José Alfredo Pérez-Ontiveros, Enrique Hong, Patrick Mailloux-Salinas, Omar Josué Saucedo-Ramírez, Blanca E. Del-Rio-Navarro, Santiago Villafaña, Eliseo Ruiz-Bedolla, Guadalupe Bravo, Fengyang Huang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Waist Adolescent Endocrinology Diabetes and Metabolism Adipokine Models Biological Receptors Tumor Necrosis Factor Body Mass Index Endocrinology Internal medicine Lifestyle intervention Medicine Homeostasis Humans Mass index Resistin Obesity Receptor Child Life Style Triglycerides Adiponectin business.industry Cholesterol HDL nutritional and metabolic diseases Female Insulin Resistance Waist Circumference business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine journal. 61(9) |
| ISSN: | 1348-4540 |
| Popis: | The aim of this study was to evaluate the effect of a six-month lifestyle intervention on adiponectin, resistin, and two soluble forms of tumor necrosis factor-α receptor (sTNFR) in obese adolescents. A total of 54 obese adolescents aged 10 to 16 years completed the program. Twenty-four adolescents with normal weight at baseline were used as a control group. Our results demonstrated that obese adolescents had abnormal lipid profile, homeostasis model assessment (HOMA) index, adiponectin level (5.6 ± 2.7 vs. 7.6 ± 2.9 μg/mL, p = 0.005) as well as resistin level (31.0 ± 9.0 vs. 24.3 ± 8.5 ng/mL, p = 0.003), whereas levels of both sTNFRs were similar to those in normal weight subjects. After the six-month lifestyle intervention, obese adolescents had a slight but significant drop in standard deviation score-body mass index (SDS-BMI), a significant decrease in waist circumference, total cholesterol, triglycerides, HOMA index, as well as resistin, and a significant increase in adiponectin and high-density lipoprotein-cholesterol. In adolescents without decreased SDS-BMI, no change was observed in adipokines. Changes in adiponectin correlated negatively with changes in waist circumference (r = -0.275, p = 0.044). Changes in resistin correlated positively with changes in triglycerides (r = 0.302, p = 0.027). The study demonstrated the increase of resistin and the decrease of adiponectin in obese adolescents. Lifestyle intervention improved adipokine abnormalities in obese subjects. |
| Databáze: | OpenAIRE |
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