Disease activated drugs: a new concept for the treatment of asthma
| Autor: | Isabelle Vachier, Reto Naef, Pascal Channez, Brigitte Charpiot, Lazzaro Mazzoni, Thomas Mueller, Karl-Heinz Buchheit, Francis Bitsch |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Budesonide Magnetic Resonance Spectroscopy medicine.drug_class Bronchoconstriction Guinea Pigs Clinical Biochemistry Pharmaceutical Science Inflammation In Vitro Techniques Biochemistry Anti-asthmatic Agent Mass Spectrometry In vivo Bronchodilator Drug Discovery medicine Animals Humans Anti-Asthmatic Agents Molecular Biology Cells Cultured Chromatography High Pressure Liquid medicine.diagnostic_test Phosphoric Diester Hydrolases Chemistry Hydrolysis Organic Chemistry respiratory system Asthma Rats respiratory tract diseases Bronchoalveolar lavage Immunology Molecular Medicine Methacholine medicine.symptom Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry. 9:1793-1805 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/s0968-0896(01)00077-3 |
| Popis: | Disease activated drugs (DAD) are pro-drugs of one active principle or combinations of two drugs, which have a proven efficacy for the treatment of the target disease. In opposition to pro-drugs, DAD are activated in inflamed but not normal tissues. Due to the disease specific activation, the amount of locally released drug(s) should be related directly to the severity of the inflammation. To test this concept in asthma a PDE4 inhibitor, an isoquinoline derivative, was chemically derivatized into pro-drugs or combined with corticosteroids. These new compounds were more readily cleaved into active PDE4 inhibitor, in bronchoalveolar lavage fluid (BALF) from Brown-Norway rats with lung inflammation than in BALF from rats without airway inflammation. The DAD concept (local selective release and improved therapeutic window) was validated in vivo using the inhibition of methacholine induced bronchoconstriction in guinea pigs with or without ozone induced lung inflammation. An example of DAD hydrolysis (isoquinoline-dexamethasone) was also examined in BALF from asthmatics and healthy volunteers. |
| Databáze: | OpenAIRE |
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