Impact of Left Ventricular End-Diastolic Wall Stress on Plasma B-Type Natriuretic Peptide in Heart Failure with Chronic Kidney Disease and End-Stage Renal Disease
| Autor: | Shunichi Miyazaki, Yoshitaka Iwanaga, Shinichiro Niizuma, Takaharu Yahata, Yodo Tamaki, Yoichi Goto, Hajime Nakahama |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.drug_class Heart Ventricles Clinical Biochemistry Diastole Renal function Kidney Function Tests urologic and male genital diseases End stage renal disease Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Aged Heart Failure business.industry Biochemistry (medical) Middle Aged medicine.disease Brain natriuretic peptide Endocrinology Heart failure Cardiology Kidney Failure Chronic Female business hormones hormone substitutes and hormone antagonists Kidney disease |
| Zdroj: | Clinical Chemistry. 55:1347-1353 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1373/clinchem.2008.121236 |
| Popis: | Background: Plasma B-type natriuretic peptide (BNP) is a diagnostic and prognostic marker in heart failure (HF). Although renal function is reported as an important clinical determinant, precise evaluations of the relationships of renal function with hemodynamic factors in determining BNP have not been performed. Therefore, we evaluated the association of plasma BNP concentrations with LV end-diastolic wall stress (EDWS) in a broad range of HF patients including those with chronic kidney disease (CKD) and end-stage renal disease (ESRD).Methods: In 156 consecutive HF patients including those with CKD and ESRD, we measured plasma BNP and performed echocardiography and cardiac catheterization. LV EDWS was calculated as a crucial hemodynamic determinant of BNP.Results: Plasma BNP concentrations increased progressively with decreasing renal function across the groups (P < 0.01) and were correlated with LV EDWS (r = 0.47) in the HF patients overall. This relationship was also present when patients were subdivided into systolic and diastolic HF (P < 0.01). In multivariable analysis, higher EDWS was associated with increased BNP concentration independently of renal dysfunction (P < 0.01). Anemia, systolic HF, and decreased BMI also contributed to increased BNP concentrations.Conclusions: These results suggest that LV EDWS is a strong determinant of BNP even in patients with CKD and ESRD. Anemia, obesity, and HF type (systolic or diastolic) should also be considered in interpreting plasma BNP concentrations in HF patients. These findings may contribute to the clinical management of HF patients, especially those complicated with CKD and ESRD. |
| Databáze: | OpenAIRE |
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