Incidence and Treatment Efficacy of Trigger Finger in the Breast Cancer Population on Aromatase Inhibitors
| Autor: | William W. Dzwierzynski, Andrew J Regent-Smith, Aaron Morgan, Evan J Childers |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.drug_class Population 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Orthopedics and Sports Medicine In patient Aromatase education 030203 arthritis & rheumatology 030222 orthopedics education.field_of_study Aromatase inhibitor biology business.industry Incidence (epidemiology) medicine.disease Treatment efficacy biology.protein Surgery Trigger finger business |
| Zdroj: | HAND. 18:250-253 |
| ISSN: | 1558-9455 1558-9447 |
| DOI: | 10.1177/15589447211017214 |
| Popis: | Background Trigger finger is a common hand complaint of the general population. Limited literature exists implicating a low-estrogen state in patients on aromatase inhibitor (AI) therapy for breast cancer who develop trigger finger. The authors’ objective was to determine the incidence and treatment outcomes of this population. Methods A single-center retrospective chart review was conducted on patients with a diagnosis of breast cancer on AI who developed trigger finger from 2010 to 2019. The total population of patients during this time served as our population, and patients with breast cancer not on AI with trigger finger served as our control. Primary outcomes included total number of injections and need for surgery. Secondary outcomes included risk factors for surgery. χ2 analysis and logistical regression model determined the significance of primary and secondary outcomes, respectively. Results In all, 192 patients of a population size of 664 751 met our study group criteria. The study group showed a higher incidence of trigger finger (5.1% vs 1.3%; P < .001) compared with our population. Patients treated with AI for breast cancer had both higher incidence of trigger finger (5.1% vs 1.5%, P < .001) and injections (77.1% vs 66.5%, P < .001) compared with patients not on AI therapy. Independent risk factors requiring surgical treatment were found in patients with diabetes (odds ratio [OR], 3.54; P = .01) and in patients with concomitant radiation therapy (OR, 3.17; P = .02). Conclusions This study demonstrates for the first time the incidence, treatment outcomes, and surgical risk factors of trigger finger in patients on AI therapy for breast cancer. |
| Databáze: | OpenAIRE |
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