Management of the non-descended testis: doubtful value of luteinizing-hormone-releasing-hormone (LHRH). A double-blind, placebo-controlled multicentre study
| Autor: | V. B. Jensen, L. H. Olsen, F. S. Jørgensen, M. Rassmussen, L. Vinzents, L. B. Lassen, L. Dammegaard, K. Bröndum‐Nielsen, H. G. Genster, N. Hofman, S. Munck, A. Mosegaard |
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| Rok vydání: | 1992 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism medicine.medical_treatment Gonadotropin-releasing hormone Placebo Retractile testis Gonadotropin-Releasing Hormone Double-Blind Method Internal medicine Scrotum Administration Inhalation Cryptorchidism medicine Humans Child Randomized Controlled Trials as Topic Chemotherapy business.industry Infant medicine.anatomical_structure Endocrinology Reproductive Medicine Nasal spray Child Preschool Luteinizing hormone business Hormone |
| Zdroj: | International journal of andrology. 15(2) |
| ISSN: | 0105-6263 |
| Popis: | In a double-blind, placebo-controlled multicentre study, the effect of luteinizing-hormone-releasing-hormone (LHRH) in 141 boys was analysed after 4-week treatment period with 0.4 mg LHRH nasal spray or placebo nasal spray three times daily. Data from 123 boys was analysed, with 62 boys in the treatment group and 61 in the placebo group. Full response i.e. the testis at the bottom of the scrotum on both sides in boys with bilaterally undescended testes, was found in six patients, one of them in the placebo group [Therapeutic gain of LHRH with 95% CI: 8.1% (0.1-16.6%, P = 0.12)]. Only in these boys could surgery be avoided. Considering the number of testes (and not the number of boys) a significant effect was found on at least one testis in 25% of boys with bilaterally undescended testes [Therapeutic gain with 95% CI: 24.0% (13.2-34.8%, P = 0.001)]. In unilateral undescended testes, the LHRH treatment showed no effect (P = 1.00). The inclusion of retractile testes did not affect our results. In our opinion LHRH has a limited place in treatment of the non-descended testis. |
| Databáze: | OpenAIRE |
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