Protein O-GlcNAcylation in cardiovascular diseases

Autor: Hui-fang Wang, Yi-xuan Wang, Yu-ping Zhou, Yun-peng Wei, Yi Yan, Ze-jian Zhang, Zhi-cheng Jing
Rok vydání: 2022
Předmět:
Zdroj: Acta Pharmacologica Sinica. 44:8-18
ISSN: 1745-7254
1671-4083
DOI: 10.1038/s41401-022-00934-2
Popis: O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e. O-GlcNAc transferase (OGT) and protein O-GlcNAcase (OGA). Protein O-GlcNAcylation mainly occurs in the cytoplasm, nucleus, and mitochondrion, and it is ubiquitously implicated in the development of cardiovascular disease (CVD). Alterations of O-GlcNAcylation could cause massive metabolic imbalance and affect cardiovascular function, but the role of O-GlcNAcylation in CVD remains controversial. That is, acutely increased O-GlcNAcylation is an adaptive heart response, which temporarily protects cardiac function. While it is harmful to cardiomyocytes if O-GlcNAcylation levels remain high in chronic conditions or in the long run. The underlying mechanisms include regulation of transcription, energy metabolism, and other signal transduction reactions induced by O-GlcNAcylation. In this review, we will focus on the interactions between protein O-GlcNAcylation and CVD, and discuss the potential molecular mechanisms that may be able to pave a new avenue for the treatment of cardiovascular events.
Databáze: OpenAIRE
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