Early Programming of T Cell Populations Responding to Bacterial Infection
| Autor: | Eric G. Pamer, Roberto Mercado, Sujata Vijh, Kristen M. Kerksiek, Ingrid M. Pilip, S. Elise Allen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Contraction (grammar)
Inflammatory response T cell Bacterial Toxins Immunology Epitopes T-Lymphocyte Mice Transgenic CD8-Positive T-Lymphocytes Biology Lymphocyte Activation medicine.disease_cause T cell response Microbiology Hemolysin Proteins Mice Mice Congenic Listeria monocytogenes T-Lymphocyte Subsets In vivo medicine Animals Immunology and Allergy Listeriosis Heat-Shock Proteins Bacterial clearance Antigen Presentation Mice Inbred BALB C Immunodominant Epitopes Cell Cycle H-2 Antigens Cell Differentiation T lymphocyte Cytotoxicity Tests Immunologic Adoptive Transfer Mice Inbred C57BL medicine.anatomical_structure Injections Intravenous Ampicillin Immunologic Memory Cell Division |
| Zdroj: | The Journal of Immunology. 165:6833-6839 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | The duration of infection and the quantity of Ag presented in vivo are commonly assumed to influence, if not determine, the magnitude of T cell responses. Although the cessation of in vivo T cell expansion coincides with bacterial clearance in mice infected with Listeria monocytogenes, closer analysis suggests that control of T cell expansion and contraction is more complex. In this report, we show that the magnitude and kinetics of Ag-specific T cell responses are determined during the first day of bacterial infection. Expansion of Ag-specific T lymphocyte populations and generation of T cell memory are independent of the duration and severity of in vivo bacterial infection. Our studies indicate that the Ag-specific T cell response to L. monocytogenes is programmed before the peak of the innate inflammatory response and in vivo bacterial replication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|