Inhibition of Gastric Lipase as a Mechanism for Body Weight and Plasma Lipids Reduction in Zucker Rats Fed a Rosemary Extract Rich in Carnosic Acid
| Autor: | Juan Carlos Espín De Gea, María-Teresa García-Conesa, Marc Roller, Emilie Fromentin, Rocío García Villalba, Alvin Ibarra, Mar Larrosa, María-Josefa Yáñez-Gascón, Francisco A. Tomás-Barberán, María Romo Vaquero |
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| Přispěvatelé: | Centro para el Desarrollo Tecnológico Industrial (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Science Biology Body weight Biochemistry Enzyme Regulation Fats chemistry.chemical_compound Model Organisms Internal medicine Plasma lipids medicine Rosemary extract Animals Gastric lipase Food science Nutrition Multidisciplinary Cholesterol Plant Extracts Body Weight Carnosic acid Animal Models Lipase Lipid Metabolism Lipids Rosmarinus Enzymes Rats Rats Zucker Enzyme Activation Endocrinology Metabolism chemistry Blood Chemistry Abietanes Rat Medicine Zucker Rats Research Article |
| Zdroj: | PLoS ONE Digital.CSIC. Repositorio Institucional del CSIC instname PLoS ONE, Vol 7, Iss 6, p e39773 (2012) |
| ISSN: | 1932-6203 |
| Popis: | [Background] Rosemary (Rosmarinus officinalis L.) extracts (REs) exhibit hepatoprotective, anti-obesity and anti-inflammatory properties and are widely used in the food industry. REs are rich in carnosic acid (CA) and carnosol which may be responsible for some of the biological activities of REs. The aim of this study was to investigate whether inhibition of lipase activity in the gut may be a mechanism by which a RE enriched in CA (40%) modulates body weight and lipids levels in a rat model of metabolic disorders and obesity. [Methods and Principal Findings] RE was administered for 64 days to lean (fa/+) and obese (fa/fa) female Zucker rats and body weight, food intake, feces weight and blood biochemical parameters were monitored throughout the study. Lipase activity (hydrolysis of p-nitrophenylbutyrate) was measured in the gastrointestinal tract at the end of the study and the contents of CA, carnosol and methyl carnosate were also determined. Sub-chronic administration of RE moderately reduced body weight gain in both lean and obese animals but did not affect food intake. Serum triglycerides, cholesterol and insulin levels were also markedly decreased in the lean animals supplemented with RE. Importantly, lipase activity was significantly inhibited in the stomach of the RE-supplemented animals where the highest content of intact CA and carnosol was detected. [Conclusions] Our results confirm that long-term administration of RE enriched in CA moderates weight gain and improves the plasma lipids profile, primarily in the lean animals. Our data also suggest that these effects may be caused, at least in part, by a significant inhibition of gastric lipase and subsequent reduction in fat absorption. This project was financed by the Spanish Centre for the Development of Industrial Technology (CDTI) as part of the project SENIFOOD, which belongs to the CENIT subvention program (Ref: CEN-20091006). |
| Databáze: | OpenAIRE |
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