Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside

Autor:	HJ Weinstein, TW Griffin, J Feeney, HJ Cohen, RD Propper, SE Sallan
Rok vydání:	1982
Předmět:	Adolescent Immunology Cytarabine food and beverages Cell Biology Hematology biochemical phenomena metabolism and nutrition Biochemistry carbohydrates (lipids) Kinetics Child Preschool Humans heterocyclic compounds lipids (amino acids peptides and proteins) Infusions Parenteral Child
Zdroj:	Blood. 59(6)
ISSN:	0006-4971
Popis:	The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intravenous infusions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0087a3950d424d53408af58abdd7d8 https://pubmed.ncbi.nlm.nih.gov/7082832 Zobrazit plný text záznamu