Sneddon's and the primary antiphospholipid syndrome: Confusion clarified

Autor: Ronald A. Asherson, Richard Cervera
Rok vydání: 2015
Předmět:
Zdroj: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 3(2)
ISSN: 1052-3057
Popis: The cases reported by Sneddon and referrred to as "Sneddon's syndrome" (1) had only cerebrovascular disease and livedo reticularis accompanied by benign hypertension in some. Sneddon linked the livedo and cerebrovascular pathology, suggesting that endarteritis obliterans similar to that occurring in the Takayasu arteriopathy might be the etiology histo­ pathologically. This has indeed been subsequently verified by several investigators (2-4). Rebollo et al. (2) showed multiple occlusions of medium-sized arteries in the brain and digital vessels by cerebro­ renal arteriography, and digital biopsy confirmed the presence of an arteriopathy. These histological fea­ tures were also identified by Quimbyand Perry (3) as well as by Pinol Aigvade et al. (4). Antiphospholipid antibodies were first documented in patients with cerebrovascular disease and livedo reticularis in a patient documented by Asherson et al. in 1985 who had originally presented with an aortic arch syn­ drome (5). The patient identified by Rumpl et al. (6) had a positive VORl, and Jonas et al. (7) then pub­ lished a case of Sneddon's syndrome with a compli­ cating retinal occlusion in the presence of antiphos­ pholipid antibodies. In other words, as early as 1985, we were already seeingliterature to the effect that the original concept of Sneddon's syndrome was slowly being extended to involve arterial occlusions in other organs. In our first report of a study on livedo reti­ cularis in 1987 (8), and subsequently followed by a full communication in 1989 (9), we pointed out that some patients with livedo reticularis with antiphos­ pholipid antibodies and cerebrovascular accidents
Databáze: OpenAIRE
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