Exploring the Spatial Drug Distribution Pattern of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
| Autor: | Veria Khosrawipour, Tanja Khosrawipour, Jürgen Zieren, Eckart Förster, David Diaz-Carballo, Urs Giger-Pabst |
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| Rok vydání: | 2015 |
| Předmět: |
Swine
medicine.medical_treatment Pharmacology 03 medical and health sciences 0302 clinical medicine medicine Pressure Animals Doxorubicin Tissue Distribution Aerosolization Aerosols Chemotherapy Antibiotics Antineoplastic business.industry Intraperitoneal chemotherapy Penetration (firestop) Aerosol Oncology Homogeneous 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Laparoscopy Peritoneum Nuclear medicine business Ex vivo medicine.drug |
| Zdroj: | Annals of surgical oncology. 23(4) |
| ISSN: | 1534-4681 |
| Popis: | Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel approach to delivering intraperitoneal chemotherapy (IPC) as a pressurized aerosol. One of the assumed advantages is the homogeneous drug distribution in the intraperitoneal cavity compared with conventional liquid in situ chemotherapy. However, to date, the spatial drug distribution pattern of PIPAC has not been investigated in detail. Doxorubicin was aerosolized in an ex vivo PIPAC model containing native fresh tissue samples of swine peritoneum at a pressure of 12 mmHg CO2 at 36 °C. In the center of the top cover of the PIPAC chamber, a PIPAC micropump was installed. Tissue specimens were placed as follows: (A) bottom of the plastic box, (B) margin of the aerosol jet covered with a bilaterally open tunnel, (C) side wall, and (D) top cover, respectively. In-tissue doxorubicin penetration was measured using fluorescence microscopy on frozen thin sections. The depth of doxorubicin penetration was found to be significantly higher in tissues directly exposed to the aerosol jet (A: 215 ± 79 µm) compared with the side wall (C: 77 ± 18 µm; p |
| Databáze: | OpenAIRE |
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