Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography
| Autor: | John C. Umhau, Norman Salem, Peter Herscovitch, Stanley I. Rapoport, Weiyin Zhou, William C. Eckelman, Kaizong Ma, Karen A. Kurdziel, Alla Polozova, Nahed Hussein, G. Esposito, James C. DeMar, Sharon Majchrzak, Richard E. Carson, Abesh Kumar Bhattacharjee |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Docosahexaenoic Acids Central nervous system QD415-436 Biology Biochemistry Brain mapping White matter Young Adult Endocrinology In vivo Internal medicine medicine blood flow Animals Humans Tissue Distribution Carbon Radioisotopes Brain Mapping medicine.diagnostic_test food and beverages Brain Cell Biology Human brain Haplorhini Middle Aged medicine.anatomical_structure n-3 polyunsaturated fatty acid Cerebral blood flow Positron emission tomography Docosahexaenoic acid Regional Blood Flow Positron-Emission Tomography lipids (amino acids peptides and proteins) Female Radiopharmaceuticals metabolism Research Article |
| Zdroj: | Journal of Lipid Research, Vol 50, Iss 7, Pp 1259-1268 (2009) |
| ISSN: | 1539-7262 |
| Popis: | Docosahexaenoic acid (DHA; 22:6n-3) is a critical constituent of the brain, but its metabolism has not been measured in the human brain in vivo. In monkeys, using positron emission tomography (PET), we first showed that intravenously injected [1-(11)C]DHA mostly entered nonbrain organs, with approximately 0.5% entering the brain. Then, using PET and intravenous [1-(11)C]DHA in 14 healthy adult humans, we quantitatively imaged regional rates of incorporation (K*) of DHA. We also imaged regional cerebral blood flow (rCBF) using PET and intravenous [(15)O]water. Values of K* for DHA were higher in gray than white matter regions and correlated significantly with values of rCBF in 12 of 14 subjects despite evidence that rCBF does not directly influence K*. For the entire human brain, the net DHA incorporation rate J(in), the product of K*, and the unesterified plasma DHA concentration equaled 3.8 +/- 1.7 mg/day. This net rate is equivalent to the net rate of DHA consumption by brain and, considering the reported amount of DHA in brain, indicates that the half-life of DHA in the human brain approximates 2.5 years. Thus, PET with [1-(11)C]DHA can be used to quantify regional and global human brain DHA metabolism in relation to health and disease. |
| Databáze: | OpenAIRE |
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