Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies
| Autor: | Qihui Wu, Jinwen Jiang, Yu Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nervous system
Parkinson's disease biology Amyloid beta General Neuroscience transcriptomics of nervous system Alternative splicing Neurosciences. Biological psychiatry. Neuropsychiatry Disease Review medicine.disease α-synuclein aggregation and spreading Aβ cascade hypothesis Transcriptome medicine.anatomical_structure Gene expression medicine biology.protein Parkinson’s disease Dementia Neuroscience Alzheimer’s disease RC321-571 |
| Zdroj: | Frontiers in Neuroscience, Vol 15 (2021) Frontiers in Neuroscience |
| Popis: | Alzheimer’s and Parkinson’s diseases (AD and PD) are amongst top of the prevalent neurodegenerative disease. One-third of PD patients are diagnosed with dementia, a pre-symptom of AD, but the underlying mechanism is elusive. Amyloid beta (Aβ) and α-synuclein are two of the most investigated proteins, whose pathological aggregation and spreading are crucial to the pathogenesis of AD and PD, respectively. Transcriptomic studies of the mammalian central nervous system shed light on gene expression profiles at molecular levels, regarding the complexity of neuronal morphologies and electrophysiological inputs/outputs. In the last decade, the booming of the single-cell RNA sequencing technique helped to understand gene expression patterns, alternative splicing, novel transcripts, and signal pathways in the nervous system at single-cell levels, providing insight for molecular taxonomy and mechanistic targets of the degenerative nervous system. Here, we re-visited the cell-cell transmission mechanisms of Aβ and α-synuclein in mediating disease propagation, and summarized recent single-cell transcriptome sequencing from different perspectives and discussed its understanding of neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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