Is it reasonable to ignore vitamin D status for musculoskeletal health?
| Autor: | Mark S. Rybchyn, David R. Fraser, Rebecca S. Mason, Tara C. Brennan-Speranza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Osteomalacia Proximal muscle weakness calcium business.industry muscle Parathyroid hormone chemistry.chemical_element Rickets Vitamin D status Review Article Calcium medicine.disease Skeleton (computer programming) 25-hydroxyvitamin D bone Endocrinology chemistry Internal medicine medicine Vitamin D and neurology Musculoskeletal health parathyroid hormone business phosphate |
| Zdroj: | Faculty Reviews |
| ISSN: | 2732-432X |
| Popis: | Severe vitamin D deficiency—25-hydroxyvitamin D (25OHD) concentrations below around 25–30 nmol/L—may lead to growth plate disorganization and mineralization abnormalities in children (rickets) and mineralization defects throughout the skeleton (osteomalacia) and proximal muscle weakness. Both problems are reversed with vitamin D treatment. Apart from this musculoskeletal dysfunction at very low vitamin D levels, there is apparent inconsistency in the available data about whether concentrations of 25OHD below around 50 nmol/L cause muscle function impairment and increase the risk of fracture. This narrative review provides evidence to support the contention that improving vitamin D status, up to around 50 nmol/L, plays a small causal role in optimizing bone and muscle function as well as reducing overall mortality. |
| Databáze: | OpenAIRE |
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