Dietary Antioxidants and Dementia in a Population-Based Case-Control Study among Older People in South Germany
Autor: | Christine A F, von Arnim, Florian, Herbolsheimer, Thorsten, Nikolaus, Richard, Peter, Hans K, Biesalski, Albert C, Ludolph, Matthias, Riepe, Gabriele, Nagel, G, Weinmayr |
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Rok vydání: | 2012 |
Předmět: |
Male
Gerontology Neuronal signal transduction medicine.medical_treatment Population Physiology Ascorbic Acid Antioxidants chemistry.chemical_compound Germany Humans Medicine Dementia education Aged Aged 80 and over Coenzyme Q10 education.field_of_study Vitamin C business.industry General Neuroscience Vitamin E Case-control study General Medicine beta Carotene medicine.disease Carotenoids Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies chemistry Case-Control Studies Population Surveillance Dietary Supplements Female Geriatrics and Gerontology business Body mass index Biomarkers |
Zdroj: | Journal of Alzheimer's Disease. 31:717-724 |
ISSN: | 1875-8908 1387-2877 |
Popis: | Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disease. Antioxidants may prevent the onset AD as high dietary intake of vitamin C and E were reported to be associated with lower risk of the disease. The objective of this study was to evaluate the serum levels of antioxidants in persons with mild dementia to test whether it is associated with lower levels of antioxidants in a cross-sectional study in the population of the "Activity and Function in the Ederly in Ulm" (ActiFE) study. Main exposure measures were vitamin C, vitamin E, β-carotene, lycopene, and coenzyme Q10 as analyzed by HPLC. Main outcome measures were mild cognitive impairment among 74 mildly demented compared to 158 age- and gender-matched controls. We found that blood vitamin C and β-carotene concentrations were significantly lower in demented than in control persons even after adjusting for school education, intake of dietary supplements, smoking habits, body mass index, and alcohol consumption (3rd versus 1st tertile: OR: 0.29, 95% CI, 0.09-0.96 and 0.13, 95% CI, 0.03-0.55, respectively). No associations were found for vitamin E, lycopene, and coenzyme Q10. Our findings suggest an association of vitamin C and β-carotene with dementia. However this is limited to the cross-sectional character of our study and longitudinal data will give further insight into this association. |
Databáze: | OpenAIRE |
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