Novel nicotinic action of the sulfoximine insecticide sulfoxaflor
| Autor: | Theodore J. Letherer, Thomas C. Sparks, James M. Hasler, John E. Casida, Cathy D. Young, Gerald B. Watson, Yuanming Zhu, Jonathan M. Babcock, Michael R. Loso |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Agonist
Insecticides medicine.drug_class Pyridines Xenopus Pharmacology Receptors Nicotinic Transfection Biochemistry Binding Competitive Insect Control Membrane Potentials chemistry.chemical_compound Neonicotinoids Radioligand Assay Xenopus laevis Imidacloprid medicine Animals Drosophila Proteins Nicotinic Agonists Molecular Biology Sulfoxaflor Acetylcholine receptor biology Sulfur Compounds Imidazoles Clothianidin biology.organism_classification Nitro Compounds Recombinant Proteins Nicotinic acetylcholine receptor Protein Subunits Nicotinic agonist Drosophila melanogaster chemistry Insect Science Aphids Oocytes Insect Proteins Female Chickens |
| Zdroj: | Insect biochemistry and molecular biology. 41(7) |
| ISSN: | 1879-0240 |
| Popis: | The novel sulfoximine insecticide sulfoxaflor is as potent or more effective than the neonicotinoids for toxicity to green peach aphids (GPA, Myzus persicae). The action of sulfoxaflor was characterized at insect nicotinic acetylcholine receptors (nAChRs) using electrophysiological and radioligand binding techniques. When tested for agonist properties on Drosophila melanogaster Dα2 nAChR subunit co-expressed in Xenopus laevis oocytes with the chicken β2 subunit, sulfoxaflor elicited very high amplitude (efficacy) currents. Sulfoximine analogs of sulfoxaflor were also agonists on Dα2/β2 nAChRs, but none produced maximal currents equivalent to sulfoxaflor nor were any as toxic to GPAs. Additionally, except for clothianidin, none of the neonicotinoids produced maximal currents as large as those produced by sulfoxaflor. These data suggest that the potent insecticidal activity of sulfoxaflor may be due to its very high efficacy at nAChRs. In contrast, sulfoxaflor displaced [(3)H]imidacloprid (IMI) from GPA nAChR membrane preparations with weak affinity compared to most of the neonicotinoids examined. The nature of the interaction of sulfoxaflor with nAChRs apparently differs from that of IMI and other neonicotinoids, and when coupled with other known characteristics (novel chemical structure, lack of cross-resistance, and metabolic stability), indicate that sulfoxaflor represents a significant new insecticide option for the control of sap-feeding insects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect