Transfer of immunoglobulin G across the isolated perfused human placental lobule
| Autor: | S. S. Armstrong-Fisher, P.H. Whiting, Abramovich, J. I. Duncan, S.J. Urbaniak, Kenneth Robert Page |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Reproductive immunology Placenta Rho(D) Immune Globulin Reproductive technology Immunoglobulin G Endocrinology Pregnancy Internal medicine Genetics medicine Humans Receptor Molecular Biology Maternal-Fetal Exchange biology Receptors IgG Immunoglobulins Intravenous Biological Transport Molecular biology In vitro Kinetics medicine.anatomical_structure Reproductive Medicine Transcytosis biology.protein Animal Science and Zoology Female Antibody Developmental Biology Biotechnology |
| Zdroj: | Reproduction, fertility, and development. 7(6) |
| ISSN: | 1031-3613 |
| Popis: | This study demonstrates that IgG transfer in vitro across the isolated perfused human placental lobule can be successfully studied by using natural forms of IgG. The transfer of anti-RhD IgG (anti-D) was measured in the presence and absence of intravenous immunoglobulin (IVIgG). When anti-D and IVIgG were present alone each crossed the placenta at about the same rate, but when both forms were present at the same time the movement of one interfered with the movement of the other. This pattern of transfer is consistent with receptor-mediated transcytosis. The interactions of IgG with trophoblastic transporters may therefore be studied without the complications that might arise from the use of conventionally labelled molecules. |
| Databáze: | OpenAIRE |
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