Sublethal Endpoints in Non-target Organism Testing for Insect-Active GE Crops
| Autor: | Jörg Romeis, John L. Teem, Marina Mühl, Richard L. Hellmich, Judith K. Brown, Xuguo Zhou, Thais B. Rodrigues, Rachel L. Melnick, Ana María Vélez, Fernando Hercos Valicente, Martin G. Edwards, Andrew Roberts, Steven L Levine, Chad J. Boeckman |
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| Přispěvatelé: | Andrew Roberts, Agriculture and Food Systems Institute, Washington, DC, Martin G. Edwards, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, Ana M. Vélez, Department of Entomology, University of Nebraska-Lincoln, Richard L. Hellmich, USDA, Corn Insects and Crop Genetics Research Unit, Ames., Xuguo Zhou, Department of Entomology, University of Kentucky, Lexington, KY, Thais B. Rodrigues, Greenlight Biosciences, Inc., Medford, MA, Rachel L. Melnick, Agriculture and Food Systems Institute, Washington, DC, Steven L. Levine, Bayer Crop Science, Chesterfield, MO, Chad J. Boeckman, Corteva Agriscience, Marina Mühl, Ministerio de Agricultura, Ganadería y Pesca, Dirección de Biotecnología, Buenos Aires, Jörg Romeis, Research Division Agroecology and Environment, Agroscope, Zurich, John L. Teem, Agriculture and Food Systems Institute, Washington, DC, FERNANDO HERCOS VALICENTE, CNPMS, Judith K. Brown, School of Plant Sciences, The University of Arizona, Tucson |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Histology media_common.quotation_subject lcsh:Biotechnology Biomedical Engineering environmental risk assessment Bioengineering Review 02 engineering and technology Insect sublethal endpoints Melhoramento Genético Vegetal Biology Bt Cry Parâmetros subletais 03 medical and health sciences Bacillus thuringiensis lcsh:TP248.13-248.65 Mode of action non-target organisms Organism Environmental risk assessment media_common Non target organism 2. Zero hunger business.industry Genetically engineered GE plants fungi Bioengineering and Biotechnology Controle Biológico 021001 nanoscience & nanotechnology biology.organism_classification Organismos não-alvo Biotechnology 030104 developmental biology RNAi Inseto Planta Transgênica 0210 nano-technology business Planta geneticamente modificada |
| Zdroj: | Frontiers in Bioengineering and Biotechnology, Vol 8 (2020) Frontiers in Bioengineering and Biotechnology Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
| ISSN: | 2296-4185 |
| Popis: | Historically, genetically engineered (GE) plants that have incorporated genes conferring insect protection have primarily used Cry proteins derived from Bacillus thuringiensis (Bt) to achieve their insecticidal phenotype. As a result, regulators have developed a level of familiarity and confidence in reviewing plants incorporating these insecticidal proteins. However, new technologies have been developed that produce GE plants that incorporate pest protection by triggering an RNA interference (RNAi) response or proteins other than Bt Cry proteins. These technologies have new modes of action. Although the overall assessment paradigm for GE plants is robust, there are ongoing discussions about the appropriate tests and measurement endpoints needed to inform non-target arthropod assessment for technologies that have a different mode of action than the Bt Cry proteins. As a result, increasing attention is being paid to the use of sublethal endpoints and their value for environmental risk assessment (ERA). This review focuses on the current status and history of sublethal endpoint use in insect-active GE crops, and evaluates the future use of sublethal endpoints for new and emerging technologies. It builds upon presentations made at the Workshop on Sublethal Endpoints for Non-target Organism Testing for Non-Bt GE Crops (Washington DC, USA, 4â??5 March 2019), and the discussions of government, academic and industry scientists convened for the purpose of reviewing the progress and status of sublethal endpoint testing in non-target organisms. Made available in DSpace on 2020-07-01T11:10:59Z (GMT). No. of bitstreams: 1 Sublethal-endpoints.pdf: 658109 bytes, checksum: b99f655b21f3494483d1a135eca41cfa (MD5) Previous issue date: 2020 |
| Databáze: | OpenAIRE |
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