Amygdala volumetry in 'imaging-negative' temporal lobe epilepsy
| Autor: | Michael P. Murphy, Simon Vogrin, Mark J. Cook, Simon Bower, K Morris, Christine Kilpatrick, I Cox |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Paper Pathology medicine.medical_specialty Electroencephalography Amygdala Temporal lobe Central nervous system disease Epilepsy Atrophy medicine Humans Retrospective Studies Hippocampal sclerosis medicine.diagnostic_test Video EEG monitoring Middle Aged medicine.disease Psychiatry and Mental health medicine.anatomical_structure Epilepsy Temporal Lobe nervous system Female Surgery Neurology (clinical) Psychology Neuroscience psychological phenomena and processes |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 74:1245-1249 |
| ISSN: | 0022-3050 |
| Popis: | Objective: Although amygdala abnormalities are sometimes suspected in “imaging-negative” patients with video EEG confirmed unilateral focal epilepsy suggestive of temporal lobe epilepsy (TLE), amygdala asymmetry is difficult to assess visually. This study examined a group of “imaging-negative” TLE patients, estimating amygdala volumes, to determine whether cryptic amygdala lesions might be detected. Methods: Review of video EEG monitoring data yielded 11 patients with EEG lateralised TLE and normal structural imaging. Amygdala volumes were estimated in this group, in 77 patients with pathologically verified hippocampal sclerosis (HS), and in 77 controls. Results: Seven of 11 “imaging-negative” cases had both significant amygdala asymmetry and amygdala enlargement, concordant with seizure lateralisation. Although significant amygdala asymmetry occurred in 35 of 77 HS patients, it was never attributable to an abnormally large ipsilateral amygdala. Compared with patients with HS, patients with amygdala enlargement were less likely to have suffered secondarily generalised seizures (p Conclusion: Abnormal amygdala enlargement is reported in seven cases of “imaging-negative” TLE. Such abnormalities are not observed in patients with HS. It is postulated that amygdala enlargement may be attributable to a developmental abnormality or low grade tumour. It is suggested that amygdala volumetry is indicated in the investigation and diagnosis of “imaging-negative” TLE. |
| Databáze: | OpenAIRE |
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