Insulin and IGF-I prevent brain atrophy and DNA loss in diabetes
| Autor: | Predrag Šerbedžija, James E. Madl, Douglas N. Ishii |
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| Rok vydání: | 2009 |
| Předmět: |
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medicine.medical_specialty medicine.medical_treatment Encephalopathy Nerve Tissue Proteins Article Cerebral edema Diabetes Mellitus Experimental Diabetes Complications Insulin-like growth factor Atrophy Cerebrospinal fluid Body Water Diabetes mellitus Internal medicine medicine Animals Insulin Insulin-Like Growth Factor I Rats Wistar Molecular Biology Pancreatic hormone Injections Intraventricular Memory Disorders business.industry General Neuroscience Brain Drug Synergism DNA Organ Size medicine.disease Rats Disease Models Animal Drug Combinations Endocrinology Treatment Outcome Neurology (clinical) business Developmental Biology |
| Zdroj: | Brain research. 1303 |
| ISSN: | 1872-6240 |
| Popis: | The aim of this study was to identify factors that regulate the bulk of adult brain mass, and test the hypothesis that concomitantly reduced insulin and insulin-like growth factor (IGF) levels are pathogenic for brain atrophy associated with impaired learning and memory in diabetes. Doses of insulin, or insulin plus IGF-I that were too small to prevent hyperglycemia were infused for 12 weeks into the brain lateral ventricles of streptozotocin-diabetic adult rats. Brain wet, water and dry weights were significantly decreased in diabetic rats; insulin prevented these decreases. The decrease in brain DNA and protein contents in diabetic rats was prevented by the combination treatment, but not by insulin alone. Levels of several glia- and neuron-associated proteins were reduced in diabetes; these reductions were also prevented by the combination treatment. Although hyperglycemia was not prevented in plasma nor cerebrospinal fluid, insulin prevented brain atrophy but not bulk DNA loss in diabetes, whereas the combination prevented both. Insulin actively prevented the loss of brain water content as well. Brain atrophy is associated with concomitantly reduced levels of insulin and IGF in other disorders such as Alzheimer's disease. |
| Databáze: | OpenAIRE |
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