Coronary and aortic vasoreactivity protection with endothelin receptor antagonist, bosentan, after ischemia and hypoxia in aged rats
| Autor: | Stéphane Tanguy, François Boucher, Bernard Swynghedauw, Christine Le Page, Bruno Riou, Anne-Laure Bulteau, Sophie Besse, Joël de Leiris |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Endothelin Receptor Antagonists
Male Nitroprusside medicine.medical_specialty Aging Time Factors Vasodilator Agents Ischemia Myocardial Ischemia Aorta Thoracic In Vitro Techniques Phenylephrine Internal medicine medicine.artery Coronary Circulation medicine Animals Vasoconstrictor Agents Rats Wistar Hypoxia Pharmacology Aorta Sulfonamides business.industry Endothelin receptor antagonist Bosentan Hypoxia (medical) medicine.disease Coronary Vessels Acetylcholine Rats Coronary arteries Oxygen Vasodilation Endocrinology medicine.anatomical_structure Vasoconstriction Reperfusion Injury Circulatory system cardiovascular system medicine.symptom business Endothelin receptor medicine.drug |
| Zdroj: | European journal of pharmacology. 432(2-3) |
| ISSN: | 0014-2999 |
| Popis: | This study investigated the effects of bosentan, a dual endothelin ET(A) and ET(B) receptor antagonist, during hypoxia-reoxygenation of senescent aorta and during ischemia-reperfusion of senescent heart. Isolated aortic rings and isolated hearts from adult and senescent rats were submitted, respectively, to hypoxia/reoxygenation (20/30 min) and to low-flow ischemia/reperfusion (45/30 min), without or with bosentan (10(-5) M). In the aorta, bosentan treatment prevented the impairment of relaxation in response to acetylcholine after hypoxia-reoxygenation at both ages. In the heart, coronary flow recovery during reperfusion, which is lower in senescents than in adults (48% vs. 76% of baseline value, respectively; P0.05) was fully prevented by bosentan. Prevention of endothelial dysfunction during reoxygenation of hypoxic aorta and of coronary vasoconstriction during reperfusion of ischemic heart with a dual endothelin ET(A) and ET(B) receptor antagonist suggests a role of endothelin in the vulnerability of aorta to hypoxia-reoxygenation, and of coronary arteries to ischemia-reperfusion, especially during aging. |
| Databáze: | OpenAIRE |
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